The twelve-month cost

Month one is the cheapest month you will have. Everything in this market is quoted monthly for exactly that reason.

Across the programmes where the monthly figure genuinely includes the medication, a year of compounded tirzepatide runs from about $1,500 at Trimi to $5,388 at Henry Meds. Same class of medication at both ends.

Why a year is the honest unit

Introductory rates lapse, memberships renew, doses climb. None of that shows up in a monthly figure, and all of it shows up in a year. Multiply everything by twelve before you compare anything — it takes a minute and it changes which option wins more often than not.

The full-year table

What the table leaves out

• Labs. Where a clinician recommends bloodwork it is usually billed separately. Mochi is explicit about this; most are quiet.
• Dose escalation. On programmes that price by dose, your bill rises as the treatment starts working. Flat-rate programmes do not do this, which over a year is worth more than most advertised discounts.
• The months you do not take it. A meaningful share of people stop within eight weeks. A prepaid annual plan does not care.
• Supplies. Syringes, alcohol pads and a sharps container. Some programmes include them; most leave you to it.
• Shipping. Usually included, occasionally not. Worth confirming.

Brand-name, for comparison

Through LillyDirect self-pay, single-dose Zepbound vials at 5 mg, 7.5 mg and 10 mg have been listed at $499/month, with lower starting doses nearer $299-$349.

Through NovoCare, Wegovy has been offered at $199/month for the first two fills through 31 December 2026, then $349/month for 0.25-2.4 mg doses. The oral form is listed between $149 and $299/month by dose.

Those are FDA-approved products. The gap against compounded programmes has narrowed a great deal since manufacturers opened self-pay channels, which is worth knowing before assuming compounded is automatically cheaper — we work through it in what you actually pay.

A worked example

1. Start month-to-month somewhere flat-rate. At Trimi that is $125 a month.
2. Budget an extra $50 to $200 once for labs, in case they are recommended.
3. Budget roughly $20 for a sharps container and spare syringes if your programme does not ship them.
4. After two dose increases, decide whether to switch to an annual plan and take the discount.
5. A realistic first year, going slowly and switching to annual at month three: roughly $1,500 to $1,980.

Full rankings in best tirzepatide providers and the cheapest programmes.