Fifty 410 vs Willow

Both sell tirzepatide. Fifty 410 costs $133 a month and Willow costs $399, a difference of $266 a month or about $3,192 a year. Here is what that difference actually buys.

Fifty 410 is prepaid blocks with no subscription. Willow is straightforward single-price plans. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though it usually is if you are paying cash and tolerate the medication well.

Put plainly. If you picked Fifty 410 over Willow and everything else went the same way, you would be $3,192 better off after a year. Whether that is the right trade depends on the differences below, not on the number alone.

Side by side

Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.

What actually separates them

They differ on 1 of the 7 things we track. Those differences are what the price gap is buying.

What Fifty 410 publishes

• Compounded tirzepatide starter protocol at $133/month, sold as a $399 three-month block.
• High-dose tirzepatide protocol at $183/month, sold as a $549 three-month block.
• Publishes unusually detailed information on 503A standards, USP 797 sterility and batch testing.
• No payment taken unless a provider approves you.

Where it wins: Genuinely no subscription — you buy a block and nothing recurs. Watch for: The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.

What Willow publishes

• Compounded tirzepatide listed at $399/month.

Where it wins: A single price with no membership arithmetic. Watch for: There is little published detail on how dose changes are handled. Ask before committing.

Where each is stronger

Fifty 410.

• Genuinely no subscription — you buy a block and nothing recurs.
• Among the lowest tirzepatide rates verified.
• Unusually detailed public explanation of 503A standards and batch testing.
• No payment taken until a provider approves you.

Willow.

• A single price with no membership arithmetic.

How they score

Fifty 410 scores higher overall at 4.2 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.

Which should you pick?

If you want the plain answer: Fifty 410, unless one of the differences above matters to you personally. Willow is not worse — it is aimed at somebody with a different problem, and paying $266 a month more for a problem you do not have is how people end up resenting a treatment that was working.

The verdict

We would tell a friend to start with Fifty 410 and move if it disappointed them. That is not a strong claim about either company; it is what the arithmetic supports when nothing else is pulling you.

Full detail in the Fifty 410 review and the Willow review.

How they sit against everyone else