Guide
Fifty 410 vs PlexusDx
$133/mo against $189/mo for tirzepatide. Which is worth it, and for whom.
Updated 2026-09-18 · Prices verified independently
Both sell tirzepatide. Fifty 410 costs $133 a month and PlexusDx costs $189, a difference of $56 a month or about $672 a year. Here is what that difference actually buys.
Fifty 410 is prepaid blocks with no subscription. PlexusDx is pharmacy transparency and genetic testing. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though it usually is if you are paying cash and tolerate the medication well.
Put plainly. If you picked Fifty 410 over PlexusDx and everything else went the same way, you would be $672 better off after a year. Whether that is the right trade depends on the differences below, not on the number alone.
Side by side
| Fifty 410 | PlexusDx | |
|---|---|---|
| Advertised from | $133 | $129 |
| True monthly cost | $133 | $189 |
| Over a year | $1,596 | $2,268 |
| Our score | 4.2 / 5 | 4.4 / 5 |
Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.
What actually separates them
They differ on 4 of the 7 things we track. Those differences are what the price gap is buying.
| Fifty 410 | PlexusDx | |
|---|---|---|
| Price is the same at every dose | No | Yes |
| Month-to-month without prepaying a block | No | Yes |
| Names the compounding pharmacy publicly | No | Yes |
| Offers an oral or sublingual option | No | Yes |
What Fifty 410 publishes
- Compounded tirzepatide starter protocol at $133/month, sold as a $399 three-month block.
- High-dose tirzepatide protocol at $183/month, sold as a $549 three-month block.
- Publishes unusually detailed information on 503A standards, USP 797 sterility and batch testing.
- No payment taken unless a provider approves you.
Where it wins: Genuinely no subscription — you buy a block and nothing recurs. Watch for: The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.
What PlexusDx publishes
- GLP-1 weight-loss programmes start at $129/month.
- Compounded semaglutide injection listed at $189/month with no membership fee and the same price at every dose.
- Clinical oversight via LionMD, with named physicians and NPI numbers published.
- Licensed providers in all 50 states; CLIA-certified labs for its testing line.
Where it wins: The most detailed pharmacy disclosure in this comparison — six named 503A partners. Watch for: The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier.
Where each is stronger
Fifty 410.
- Genuinely no subscription — you buy a block and nothing recurs.
- Among the lowest tirzepatide rates verified.
- Unusually detailed public explanation of 503A standards and batch testing.
- No payment taken until a provider approves you.
PlexusDx.
- The most detailed pharmacy disclosure in this comparison — six named 503A partners.
- Names its prescribing physicians along with their NPI numbers.
- No membership fee, and flat pricing across the dose range.
- Genetic and blood testing available alongside the prescription.
How they score
| What we weigh | Weight | Fifty 410 | PlexusDx |
|---|---|---|---|
| True monthly cost | 30% | 4.8 | 4.6 |
| Price honesty | 20% | 4.6 | 4.5 |
| Clinical support | 20% | 3.5 | 3.8 |
| Pharmacy sourcing | 15% | 4.2 | 4.9 |
| Cancelling | 15% | 3.3 | 4 |
PlexusDx scores higher overall at 4.4 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.
Which should you pick?
If you want the plain answer: Fifty 410, unless one of the differences above matters to you personally. PlexusDx is not worse — it is aimed at somebody with a different problem, and paying $56 a month more for a problem you do not have is how people end up resenting a treatment that was working.
The verdict
We would tell a friend to start with Fifty 410 and move if it disappointed them. That is not a strong claim about either company; it is what the arithmetic supports when nothing else is pulling you.
Full detail in the Fifty 410 review and the PlexusDx review.
How they sit against everyone else
| # | Provider | Advertised | True monthly | Score |
|---|---|---|---|---|
| 1 | Coreage Rx Top pick Best overall on true monthly cost | $149 | $199 | 4.5 |
| 2 | Trimi Lowest flat price with named pharmacies | $125 | $125 | 4.6 |
| 3 | PlexusDx Pharmacy transparency and genetic testing | $129 | $189 | 4.4 |
| 4 | Ozari Health Lowest advertised semaglutide price | $125 | $125 | 4.4 |
| 5 | Fifty 410 Prepaid blocks with no subscription | $133 | $133 | 4.2 |
| 6 | Ivím Health Unlimited clinician access | $199 | $199 | 4 |
| 7 | Mochi Health Insurance concierge support | $199 | $278 incl. $79 fee | 3.6 |
| 8 | Coby Health Multi-month value with supplies included | $179 | $239 | 3.6 |
Read next
- Fifty 410 tirzepatide review
Prepaid blocks with no subscription. We checked the advertised price against what you are actually billed. True cost: $133 a month.
- PlexusDx tirzepatide review
Pharmacy transparency and genetic testing. We checked the advertised price against what you are actually billed. True cost: $189 a month.
- How to spot a bad seller
The FDA sent more than 55 warning letters to online GLP-1 sellers in one day. Here is how to tell a licensed programme from the rest.
- The twelve-month cost
Month one is the cheapest month you will have. Here is the full-year arithmetic, including the costs nobody puts in the advert.
- The best tirzepatide providers in 2026
21 programmes compared on what you actually pay in month two — not the teaser rate. Coreage Rx comes first.
Coreage Rx pays us a commission on sign-ups through our links. It does not affect our scores or rankings. How we rate · Disclosure